Ameloblastic fibroodontoma radiology reference article. Among the malignant odontogenic tumors mots, ameloblastic fibrosarcoma afs is the most common. Ameloblastic fibrosarcoma an uncommon odontogenic tumor of right maxilla. Two 3% feline histopathological diagnoses were odontogenic tumors. A cytologists perspective ameloblastic fibrosarcoma. Malignant transformation of ameloblastic fibroma to.
Ameloblastic fibroma af is a rare, slowgrowing benign neoplasm, comprised of tissues of odontogenic origin. An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. Surgery is often performed as primary therapy, but may be limited due to anatomical or. Ameloblastic fibrosarcoma afs or ameloblastic sarcoma is an extremely rare odontogenic neoplasm. Radiographs show a radiolucent mass with illdefined borders. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an. To integrate the available data published to date on ameloblastic fibromas af and ameloblastic fibrosarcomas afs into a comprehensive analysis of their clinicalradiological features. Ameloblastic fibrosarcoma is a rare odontogenic malignancy distinct from fibrosarcoma of bone. Ameloblastic fibrosarcoma arising in the mandible semantic scholar. Some authors consider it as a phase between ameloblastic fibroma and ameloblastic fibroodontoma, because these 3 tumors, which were classified as mixed odontogenic tumors, have similarities in histodifferentiation. The authors report afs in the maxillary sinus of a 4monthold boy. Report of a rare case jahanshah salehinejad, adineh javadian langaroodi, reza shahakbari, neda yazdani 10.
This is the typical histological change occurring during malignant transformation from ameloblastic fibroma to ameloblastic fibrosarcoma prein et al. Here is described a case of ameloblastic fibrosarcoma afs affecting the posterior mandible of a woman who was treated. Aims ameloblastic fibrosarcoma afs is an aggressive odontogenic neoplasm featuring malignant mesenchymal stroma in addition to an. A case of ameloblastic odontosarcoma ameloblastic fibro.
Ameloblastic fibrosarcoma afs is a rare malignant tumor. Ameloblastic fibrosarcoma afs is a rare mixed odontogenic tumor composed of benign epithelial and malignant ectomesenchymal components. Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. A manual search of all related oral pathology, maxillofacial and specialist and oral journals was performed. Many cases formerly called fibrosarcoma are actually dedifferentiated liposarcoma, fibromatosis, fibrosarcomatous dfsp, lowgrade fibromyxoid sarcoma, mpnst, synovial sarcoma or mfhpleomorphic usually deep soft tissue of lower extremities or trunk, only rarely in retroperitoneum or mediastinum 50% recur, 25% metastasize lung, bone. The ameloblastic fibroma is a rare neoplasm that occurs mostly in children and teenagers. It is defined as an odontogenic tumor composed of malignant ectomesenchyme in which variable quantities of a benign epithelial component can be seen.
Consequently, no standard treatment or guidelines have been made available. Histologic examination of the surgical specimen revealed various. Ameloblastic fibrosarcoma afs is a malignant odontogenic tumour characteristically composed of a benign epithelium and a malignant mesenchymal component. Benign epithelium and a malignant mesenchymal component. The first report of afs was published by heath in 1887. They are, the follicular pattern, plexiform pattern, acanthomatous. Department of pathology, chittaranjan national cancer institute, kolkata, india. A case report hyunho chang, dds, msd, phd michael s. In the course of the disease, the mesenchymal component of ameloblastic fibroma showed a dramatic histopathological transformation into sarcoma. Ameloblastic fibrosarcoma afs is an aggressive odontogenic neoplasm featuring malignant mesenchymal stroma in addition to an ameloblastic epithelial component, and is hence considered to be the malignant counterpart of ameloblastic fibroma af. The majority of afs cases reported in the literature arise in the mandible. Odontogenic tumours can pose significant diagnostic challenges for the pathologist because of their relatively low incidence, somewhat overlapping histology and subtle differentiating features. At histopathological examination, the margins were tumor free. Ameloblastic fibrosarcoma is a rare malignant odontogenic.
It mainly presents as a painful maxillary or mandibular swelling. Ameloblastic fibroma, differential diagnosis, incidental finding, mixed image, radiographic features. Pdf ameloblastic fibrosarcoma afs is a rare malignant mixed odontogenic tumor which. Ameloblastic fibroma, is a mixed odontogenic tumor, which commonly affects young children under the age of 20 years, with the mandibular premolarmolar. Pot consists of dental papillalike myxoid connective tissue covered with a delicate membrane of ameloblastic epithelium. In neoplastic cases, it may be labeled an ameloblastic fibrosarcoma in accord with the terminological distinction that reserves the word fibroma for benign tumors and assigns the word fibrosarcoma to malignant ones. Histologically, the tumor showed biphasic components.
It is also radiolucent and expansile so that its clinical and radiographic pattern will be similar to an ameloblastoma and to an odontogenic myxoma fig. Ameloblastic fibrosarcoma afs is a rare malignant odontogenic neoplasm, first described by heath in 1887. One case was a peripheral odontogenic fibroma pof, and one was an ameloblastic fibroodontoma. There are six different patterns of manifestation for ameloblastoma under the microscope. A primordial odontogenic tumor pot is a rare, benign, mixed epithelial and mesenchymal odontogenic tumor that has been included as a new entity in the latest world health organization who classification 2017. The recommended safe margin for unicystic ameloblastoma, multicystic ameloblastoma, and ameloblastic carcinoma is proposed to be 11. Ameloblastic fibrosarcoma of mandible in a paediatric. An analysis of previously reported fatal cases of ameloblastic fibrosarcoma is included. A rare case appearing as a mixed radiographic image. This report presents a fatal case of ameloblastic fibrosarcoma arising from an ameloblastic fibroma, originating in the maxilla of 19yearold japanese male.
Afs is composed of a benign odontogenic epithelium and a malignant mesenchymal component. Sarcomas are rare diseases of the head and neck region, representing around 1% of all malignancies. Radical surgical excision and longterm followup are the. It is regarded as the malignant counterpart of ameloblastic fibroma af. Ameloblastic fibroma of the mandible reconstructed with. Thus, the lesion was diagnosed as ameloblastic fibrosarcoma. Ameloblastic fibrosarcoma in the maxilla, malignant. Ameloblastic fibroma and ameloblastic fibrosarcoma. The diagnosis is made by histopathological and immunohistochemical evaluation, since the epithelial component remains.
Current concepts of odontogenic tumours diagnostic. Aggressive ameloblastic fibrosarcoma in maxilla scielo. The disease is characterized by bone destruction and swelling with pain. In neoplastic cases, it may be labeled an ameloblastic fibrosarcoma in accord with the terminological distinction that reserves the word fibroma for benign tumors and assigns the. Based on histological results, malignant neoplasms comprised the diagnosis in 34 47% cases. It constitutes 2% of odontogenic tumours, occurring at any age, but has a predilection to present in the first two decades of life. Histopathological diagnosis can be challenging, especially when it is based. Pathology outlines fibrosarcoma of soft tissue adult. However, most cases were diagnosed as primary malignant processes 15. Evaluation of the effects of ethanolic extract of sesamum indicum seeds on sperm. It is characterized by epithelial islands and cords immersed in ectomesenchyme that mimics the dental.
According to the 2005 who classification of odontogenic tumors, it is defined as a benign tumor that resembles ameloblastic fibroma but contains enamel and dentin. Histopathology showed malignant features of sarcoma, such as nuclear crowding, with hypercellularity and variable degrees of cytological atypia. Amongst them, ameloblastic fibrosarcoma afs is of even greater rarity, with less than 100 cases reported in the literature. Ameloblastic fibroodontoma afo is a rare benign mixed odontogenic tumor that usually arises in the maxilla and mandible. It may be either truly neoplastic or merely hamartomatous an odontoma. A survey of cases from the armed forces institute of pathology. The former is characterized by areas of a benign odontogenic epithelium interspersed with areas of fibrosarcoma. Afs is exceedingly rare, with fibroodontosarcoma, panoramic radiograph, computed tomography imaging odontogenic tumours are very infrequent lesions, accounting for less than 4% of all oral and maxillofacial specimens. Despite similar histologies, the biological behaviour and appropriate therapy differ significantly between entities and accurate diagnosis is therefore essential. Journal of veterinary dentistry histopathologic diagnoses. On the contrary, the odontogenic epithelial component is bland and cytologically benign. A 35yearold male presented with an asymptomatic left maxillary mass that. Ameloblastic fibrosarcoma afs is a rare malignant odontogenic tumour classified by the who 1992 as an odontogenic sarcoma and defined as a neoplasm with a similar structure to ameloblastic fibroma af but in which the ectomesenchymal component shows the features of a sarcoma.
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